[3] General Hospital was founded by members of the Woman's Book Club of Everett in 1894,[6][7] with the cornerstone being laid in an existing building at 3322 Broadway.

[8] In 1923, a group of businessmen rallied the community and raised $150,000 to purchase a new site and construct a modern hospital with 74 beds, which opened on February 27, 1924.

In 2008, to better reflect its role in the area, the hospital changed its name to Providence Regional Medical Center Everett.

[11] The Marshall and Katherine Cymbaluk Medical Tower opened at the Colby campus in June 2011.

[12] In October 2019, professional and technical employees at the hospital represented by the United Food and Commercial Workers (UFCW) authorized a strike, citing what they perceived were inadequate offers from hospital administrators; both sides eventually reached an agreement on January 8, 2020, after the union announced plans to strike the prior week.

[13][14] More than a year later, on June 4, 2021, nurses at the hospital additionally represented by the union authorized a strike as well despite beginning negotiations with hospital administrators in October 2020; they also cited inadequate offers from the administrators along with major stress and resulting burnout due to the COVID-19 pandemic.