[2] In 1897, it shifted location to the Sarah B. Yesler home at Second Avenue North and Republican Street.

In 1899, following acquisition by the Deaconess Home Society of the Methodist Church, funds were raised to build a new five-story hospital at 909 Fifth Avenue, which opened in November 1900.

[2] Between 1897 and 1938, 598 student nurses were trained at the hospital, but it ceased being run by the Methodist church in 1935.

[2] Between 1952 and 1958, the Fifth and Marion building was extended to provide for new surgery facilities, laboratories and beds.

Sale of the downtown site to the Bank of California led to negotiations with the Steward's Foundation, owners of the Maynard Hospital at University and Summit.