[2] Rodríguez spent 2013 in the rookie-league-level Gulf Coast League with the Gulf Coast League Nationals, who that year finished their regular season with a record of 49-9, giving them the highest winning percentage (.845) for a full regular season ever achieved by a minor-league baseball team based in the United States.

[2] Demoted to play for the Auburn Doubledays in the Low-A New York-Penn League in mid-June, Rodríguez had more success at the lower level, going 1–0 with an ERA of 2.76 in three games, all of which he started, with nine strikeouts and four walks over the 17+1⁄3 innings he pitched.

[7] He began the season by posting a 3–2 record and a 3.51 ERA, with a strikeout-to-walk ratio of almost four-to-one, and he held opposing batters to a .228 batting average.

[8] The Washington Post noted the rarity of the suspension for the Nationals, reporting that he was the team's only "prominent" minor-league player to be suspended for performance-enhancing drugs over the previous five years.

[9] He returned to action with Potomac after serving his suspension, and in 2017 overall he made 12 appearances, 10 of them starts, posted a record of 4–3 and an ERA of 3.32, struck out 51, and walked 19 in the 57 innings pitched.

[11] In a preseason listing before the start of the 2018 season, MLB Pipeline ranked Rodríguez as the Nationals' 17th-best prospect and suggested he could end up in a late-inning bullpen role.

[13] Rodríguez had appeared in 11 games for Harrisburg, all of them starts, in 2018, posting a record of 4–3 with a 3.88 ERA, 60 strikeouts, and 23 walks in 58 innings, when the Nationals called him up again on June 3.

[18] Rodríguez had made 13 starts and pitched 68 innings for Harrisburg during the season, posting a 3.31 ERA for the Senators with 72 strikeouts and 28 walks,[19] when on June 19 the Nationals recalled him to make his second career MLB appearance, first MLB start, and first appearance at Nationals Park in Washington, D.C., in that evening's Beltway Series game against the Baltimore Orioles.

[19] On November 30, 2018, Rodríguez was traded to the Cleveland Indians, along with minor leaguer Daniel Johnson and a player to be named later (revealed to be Andruw Monasterio), for Yan Gomes.

[22] On December 22, 2020, Rodríguez signed a minor league contract with his former team, the Washington Nationals, that included an invitation to 2021 spring training.