They became the first team since the 2003 Detroit Tigers, who suffered a similar fate when they went 43–119, to have fewer than 50 wins in a full 162-game season.

The Orioles held a losing record against all American League teams, ensured by their loss to the Houston Astros on September 28.

The 2018 Orioles also set the MLB record of earliest playoff exit since the divisional era came to play in 1969, being eliminated from postseason contention on August 20, 2018.

[1] The White Sox elimination occurred despite the MLB adding an extra wild card spot to its playoff field.

[1] To further add to the team's abysmal season, many of their key contributors including Manny Machado, Zack Britton, Jonathan Schoop, Darren O'Day, Kevin Gausman, and Brad Brach all left the team via trades in the trade deadline.