The school's athletics department competes in the Ottawa-Kent Conference.

[4] Jenison High School offers 18 different Advance Placement (AP) courses.

State Champions, First Place in MCBA Flight II, 2001, 2002, 2004, 2011, 2012, 2013, 2017, 2018, 2019, 2021, 2022, 2023, 2024 Northwest Ohio Regional Champions, First Place in BOA Class AA, 2022, 2023 Other Achievements: Macy's Thanksgiving Day Parade, 2023 State Champions, Class A, 1987, 1988, 1990, 1992, 1994, 1995[5] The softball field is named after Jerry Hoag, head coach of all Jenison's State Championship softball teams.

The Wildcats play in David McKenzie Stadium, which is named after one of the districts former superintendents.

The Jenison/Zeeland Varsity hockey team plays their games in Georgetown ice arena.