He received numerous honors including being named to the USA today All-USA First-team,[2] Scout.com All-American second-team, Super Prep All-Midwest, Prep-Star All Midwest, All-State and Detroit News All-Detroit and the Dream Team "MVP.

He attended pre-draft visits with multiple teams, including the New England Patriots, Pittsburgh Steelers, Jacksonville Jaguars, and Cleveland Browns.

[21] Head coach Mike McCarthy named Perry and Clay Matthews III the starting outside linebackers to begin the regular season.

He made his professional regular season debut in the Green Bay Packers’ season-opener against the San Francisco 49ers and collected a season-high eight combined tackles during their 30–22 loss.

On September 24, 2012, Perry recorded four combined tackles and made his first career sack as the Packers lost 14–12 at the Seattle Seahawks in Week 3.

Head coach Mike McCarthy named Perry a backup outside linebacker to start the regular season, behind Clay Matthews III and Julius Peppers.

[32] He finished the 2014 NFL season with 22 combined tackles (16 solo), three sacks, one pass deflection, and one forced fumble in 15 games and four starts.

On January 11, 2015, Perry recorded four combined tackles and made 1.5 sacks during a 26–21 victory against the Dallas Cowboys during the NFC Divisional Round.

[38] Perry finished the 2015 NFL season with 31 combined tackles (16 solo), 3.5 sacks, one pass deflection, and one forced fumble in 14 games and one start.

On January 10, 2016, Perry recorded four combined tackles and made 2.5 sacks during a 35–18 win at the Washington Redskins during the NFC Wildcard Game.

[19][40][41][42] Perry entered training camp slated as a backup outside linebacker, but began competing against Julius Peppers for a starting role.

[45] On October 20, 2016, Perry made four combined tackles, a pass deflection, a sack, and his first career interception during the Packers’ 26–10 victory against the Chicago Bears in Week 7.

Perry intercepted a pass by Bears’ quarterback Matt Barkley, that was originally intended for running back Jordan Howard, to seal the Packers’ victory at the end of the fourth quarter.

He finished the 2016 NFL season with 52 combined tackles (35 solo), a career-high 11 sacks, four pass deflections, and one interception in 14 games and 12 starts.

On January 15, 2017, Perry recorded four solo tackles, deflected a pass, and made a sack during a 34–31 win at the Dallas Cowboys in the NFC Divisional Round.

[49][19][50] Perry entered training camp slated as a starting outside linebacker after Julius Peppers departed in free agency.

[51] On September 21, 2017, Green Bay Packers’ head coach Mike McCarthy announced that Perry would undergo surgery to repair his injured hand.

[54] On December 30, 2017, the Green Bay Packers places Perry on injured reserve due to injuries to his ankle and shoulder.

[56] On January 10, 2018, the Green Bay Packers announced their decision to hire former Cleveland Browns’ head coach Mike Pettine as their new defensive coordinator.

On November 24, 2018, the Green Bay Packers placed Perry on injured reserve due to a knee injury.

[58] On December 3, 2018, the Green Bay Packers announced their decision to fire head coach Mike McCarthy after they fell to a 4–7–1 record.