Jesse Lazear (December 12, 1804 – September 2, 1877) was a Democratic member of the U.S. House of Representatives from Pennsylvania.

Lazear was elected as a Democrat to the Thirty-seventh and Thirty-eighth Congresses.

He served as chairman of the United States House Committee on Expenditures on Public Buildings during the Thirty-seventh Congress.

He retired to his country home, "Windsor Mill Farm", in Woodlawn, Baltimore County, Maryland, in 1867.

Lazear died at his country home in 1877 and was interred in the Green Mount Cemetery in Waynesburg.