[1] Originally named The Jewish Hospital, the organization was established in either 1847[2] or 1850[1][3] in response to a cholera epidemic for treating the affected Jewish population of Cincinnati.

It was also a reaction to the fact that at other hospitals Jewish patients were subject to pressure from Christian missionaries seeking deathbed conversions, and also to provide for kosher dietary concerns of observant Jews.

It was the first anchor of what would become known as Pill Hill as more hospitals were built nearby.

[6] The Jewish Hospital has earned accolades and distinction from various health ranking services, and is a former member of the Health Alliance of Greater Cincinnati, likewise a nationally recognized organization.

[7][8] In 2009, Mercy Health, also in Cincinnati, purchased the hospital for approximately $108 million.