Prior to the 2005 season, UWA head football coach Sam McCorkle cited in a Tuscaloosa News article that Fatu would be one of the players to watch.

[12][13] Realizing his football career was not heading down a desirable path, Fatu and his brother Jonathan decided to join his father Solofa (Rikishi) and uncle, Eddie (Umaga) in the wrestling business.

On March 13, The Usos defeated The Fortunate Sons (Joe Hennig and Brett DiBiase) to win the FCW Florida Tag Team Championship.

[33] The Usos defeated The Hart Dynasty for the first time in a six-person mixed tag team match on the July 12 episode of Raw when Jey pinned Smith.

[36] On the June 2 episode of Superstars, The Usos turned face when they competed against The Corre (Justin Gabriel and Heath Slater) in a losing effort.

[38][39] On the July 29 episode of SmackDown, The Usos challenged David Otunga and Michael McGillicutty for the WWE Tag Team Titles, but were defeated.

On the June 3 episode of Raw, The Usos began to use face paint similar to their deceased uncle Eddie Fatu, also known as Umaga, as a means of further highlighting their Samoan culture.

At the WrestleMania XXX pre-show on April 6, The Usos successfully defended their titles in a fatal four-way elimination match against Ryback and Curtis Axel, The Real Americans, and Los Matadores.

The Usos then feuded with The Wyatt Family, successfully retaining the championships against Harper and Rowan on June 29 at Money in the Bank and in a two-out-of-three falls match at Battleground on July 20.

He returned on the November 2 episode of Raw alongside his brother Jimmy as a surprise return to team up with their cousin Roman Reigns, Dean Ambrose and Ryback against Seth Rollins, Kevin Owens and The New Day in a Survivor Series elimination tag team match, The Usos along with Reigns, Ambrose and Ryback were victorious in the match.

Later that night, Stephanie McMahon told The Usos that they would be inserted to the tag team championship match at the TLC pay-per-view if Roman Reigns defeated Sheamus during the main event of the show in 5 minutes and 15 seconds, which he won by disqualification.

At Extreme Rules on May 22, The Usos lost to Gallows and Anderson in a Texas Tornado match, but helped Reigns retain his title in the main event.

[59] On the April 11 episode of SmackDown Live, The Usos were successful in their first title defense by defeating American Alpha in a rematch, ending the feud.

[64] Their reign ended on the September 12 episode of SmackDown Live after they lost to The New Day in a Sin City Street Fight,[65] but regained the titles on October 8 at Hell in a Cell.

[68] At Clash of Champions on December 17, The Usos retained the titles in a fatal four-way tag team match against Chad Gable and Shelton Benjamin, The New Day (Big E and Kofi Kingston) and Rusev and Aiden English.

[70] They would renew their rivalry with the New Day, culminating in a title match at Fastlane on March 11, which would end in a no-contest due to interference from The Bludgeon Brothers.

[74] On the May 22 episode of SmackDown, The Usos attempted to earn another title match at Money in the Bank, but were defeated by Luke Gallows and Karl Anderson.

[75] Following the loss, The Usos began failing to earn numerous title opportunities, including a tag team match against a returning Team Hell No (Daniel Bryan and Kane) on the July 3 episode of SmackDown and losing in the first round of a number one contender's tournament to The Bar (Cesaro and Sheamus) on the July 31 episode of SmackDown.

[77] They would go on to challenge The Bar for the SmackDown Tag Team Championship in a triple threat match, which also included the New Day at TLC on December 16, but failed to capture the titles.

[81] As a storyline punishment for their deed, they were scheduled to defend the titles against The Bar, Aleister Black and Ricochet, and Shinsuke Nakamura and Rusev in a Fatal 4-Way at WrestleMania 35 on April 7,[82] which they won.

[109][110] During the Money in the Bank Kickoff pre-show on July 18, The Usos were successful in capturing their fifth SmackDown Tag Team Championship from The Mysterios (Rey and Dominik).

[114] At WrestleMania Backlash on May 8, The Usos and Reigns defeated RK-Bro (Randy Orton and Riddle) and Drew McIntyre in a six-man tag team match.

[139] Uso returned at Payback on September 2, appearing on The Grayson Waller Effect with Cody Rhodes announcing that he would be switching brands from SmackDown to Raw.

[140] At Fastlane on October 7, Uso and Rhodes defeated Bálor and Priest to win the Undisputed WWE Tag Team Championship, but lost it 9 days later.

[144] The following night, Uso interfered in the main event between Reigns and Cody Rhodes, attacking Jimmy and spearing him through a table at the entrance ramp.

The next night on Raw, Uso won a fatal four-way match to become the number one contender for the World Heavyweight Championship for Backlash France thanks to CM Punk.

[151] On the September 9 episode of Raw, Uso defeated Pete Dunne, Ilja Dragunov, and Braun Strowman in a fatal four-way match to become the number one contender for the Intercontinental Championship.

[160] At Saturday Night's Main Event on January 25, 2025, Uso challenged Gunther for the World Heavyweight Championship, but failed to win the title.

He also appeared uncredited in Countdown with Dolph Ziggler, Roman Reigns, and Big Show and his brother Jimmy Uso as well as the animated film The Jetsons & WWE: Robo-WrestleMania!, which he played a role as Usobots.

As a result, Joshua was forced to wear a version of his "Yeet" shirts with the trademarked text blurred out on the print itself,[171] on that week's WWE television programming.