During his tenure with NRBQ, he and bandmates Johnny Spampinato, Adams and Tom Ardolino were featured in animated form on an episode of The Simpsons.

The group served as the unofficial "house band" for The Simpsons for the season 10–12 period during which time longtime NRBQ fan Mike Scully was head writer and executive producer of the show.

The band also appeared in non-animated form on camera during the end credits to perform the show's theme song during the episode "Take My Wife, Sleaze".

When the NRBQ stopped touring and recording in 2004 due to Adams's diagnosis of throat cancer, Spampinato and his brother, Johnny, continued for a short while with Tom Ardolino in the band Baby Macaroni.

Johnny replaced NRBQ's previous guitarist Al Anderson, who left the group in 1994 to pursue a career as a songwriter, producer and session player in Nashville.

During 2012, The Spampinato Brothers embarked on a tour in Japan, showcasing their new material in addition to fan favorites from their years with NRBQ.