Johnny replaced NRBQ's previous guitarist Big Al Anderson, who left the group in 1994 to pursue a fruitful musical career as a respected songwriter, producer and session player in Nashville.
The group served as the unofficial "house band" for The Simpsons for the season 10-12 period in which longtime NRBQ fan Mike Scully was head writer and executive producer.
The band also appeared in non-animated form on camera during the end credits to perform the show's theme song during the episode "Take My Wife, Sleaze".
In 2011, The Spampinato Brothers released their first full-length album, entitled "Pie In The Sky," which featured eleven songs written by Joey and Johnny with input from the band's guitarist Aaron Spade and drummer J. Cournoyer.
During 2012, The Spampinato Brothers embarked on a tour in Japan, showcasing their new material in addition to fan favorites from their years with NRBQ.