John Dempsey Hoblitzell Jr. (December 30, 1912 – January 6, 1962) was an American politician from West Virginia.

He was active in community service and civic affairs, serving as the first president of the West Virginia Junior Chamber of Commerce (1939–1940).

In addition, he was chairman of the Governor's West Virginia Commission on State and Local Finance (1954).

On January 25, 1958, he was appointed to the U.S. Senate to fill the vacancy caused by the death of Matthew M. Neely.

Hoblitzell died of a heart attack in Clarksburg, West Virginia, in 1962 and was interred in Mount Olivet Cemetery in his native Parkersburg.