[1][2] John was the son of Rhys ab Gwilym by Gwenllian, daughter of Howel Madoc, and was born in Brecon.
From a statement of Rowland Lee, it appears that Prise had been some time in the service of the Earl of Arundel as constable of Cloon Castle in Ireland, and that for his employment he was promoted to be one of Thomas Cromwell's agents.
In May 1532, when the Earls of Westmorland and Cumberland and Sir Thomas Clifford searched Cuthbert Tunstall's house at Bishop Auckland, Price looked into the manuscripts, and made a report to Cromwell.
He took part in public affairs, for example in the union of England and Wales, drafting or suggesting the petition on which the statutes were framed.
[5] He wrote: He is also said to have translated and published the Lord's Prayer, Creed, and Ten Commandments in Welsh, for the first time, in Yn y lhyvyr hwnn (1546).