The Johnathan True House is a historic home at 43 East Main Street in the Lower Falls area of Yarmouth, Maine.

Built in 1780, before Yarmouth's secession from North Yarmouth, it is one of the oldest surviving buildings in the town.

Between 1780 and the turn of the 19th century, Lower Falls saw an increase in its population after early settlers gradually moved inland from the area around the Meetinghouse under the Ledge on Gilman Road.

[1][2][3] The home was originally built for Johnathan True, a clothier who owned a store at Lower Falls.

[2][3] The rear of the property now overlooks Interstate 295 after it was built above Yarmouth's harbor in 1961.