She posed for a clothed fashion layout in Playboy in April 2002, and was later interviewed by the magazine for its "20Q" section in February 2005.

She made her television debut on the sitcom Veronica's Closet, before guest appearances on Love Boat: The Next Wave, CSI: Crime Scene Investigation, and JAG.

[4]In Enterprise, Blalock played Subcommander T'Pol, a Vulcan diplomat on Earth who was initially assigned by Vulcan Ambassador Soval (a recurring role played by Gary Graham) as an observer on the ship's first mission, in the pilot episode "Broken Bow".

At the end of that episode, she is asked to remain on Enterprise as its Science Officer by Captain Jonathan Archer (played by Scott Bakula).

Early in the fourth season, she formalizes her position in Starfleet and is granted a field commission of Commander, retaining her role as the ship's First Officer, where she remained for the rest of the series.

[citation needed] Blalock guest-starred in two episodes of Stargate SG-1 as Ishta, leader of a group of rebel female warriors.

[8] In Starship Troopers 3: Marauder, which was released direct-to-video on August 5, 2008, Blalock played Captain Lola Beck who led a mixed group of survivors on a journey across an alien infested wasteland.

[citation needed] Blalock played Lexa, the wife of a hospitalized porn star, in the 2009 episode "Teamwork" on the series House.

[11] Blalock's most recent film roles were in the direct-to-video Killing Frisco (2014) and then the TV movie A Man for Every Month (2017).