[1] Chase's paintings and drawings focus primarily on queer black bodies in mundane, everyday spaces.
[6] Chase's practice is a process of traditional and digital collage, drawing, photography, poetry, archiving, and research.
[5] Chases's figurative paintings stand stylistically beside peers Louis Fratino, Nicole Eisenman, and Carroll Dunham, and equally reference the erotic woodblock prints of Ukiyo-e.[7] Artist and curator Tiona Nekkia McClodden writes of Chase's paintings, "The figures mirror each other, touch each other … reach through each other.
"[9] Writer Miss Rosen says of Chase, "Imagine the love child of Missy Elliott and Romare Bearden, raised by Ren & Stimpy, and embracing the intimacies of James Baldwin's Giovanni's Room … and you can begin to grasp the intricate complexities and exquisite nuances of African-American artist Jonathan Lyndon Chase."
Chase notes artists Romare Bearden, Alison Saar, Marlon Riggs, Robert Colescott, Alice Neel, and Kerry James Marshall as key inspirations as well as culture and fashion from the 1980s and 1990s, Afrofuturism, and science-fiction in relationship to black and queer narratives.