A first-generation American, Roumie's father was born in Egypt and is of Syro-Lebanese descent; his mother is from Ireland.

[6] In 2024, he was awarded an honorary doctorate in fine arts by the Catholic University of America for his work evangelizing through his acting career.

[11] After graduating from college, Roumie played drums in his friend's contemporary rock band.

[14] He portrayed charismatic hippie evangelist Lonnie Frisbee in the 2023 film Jesus Revolution.

[16] Roumie started as a production assistant and was the location scout for Spider-Man, National Treasure and I Am Legend.

[19] Jonathan Roumie appeared in the Super Bowl 2024 commercial for the app, causing a huge spike in downloads Hallow.

Previous to being offered the role of Jesus Christ in 2017 for what was then a new television series, The Chosen, Roumie states he had reached a point on his life where he had completely surrendered himself to God.

"[23] Now known worldwide for portraying Jesus in the series,[24] Roumie has been featured in numerous publications, including TV Guide, the National Catholic Register,[10] America Magazine,[25] and The Atlantic,[26] and The New Yorker.

"[30] Roumie has been a ministry leader and has served as an extraordinary minister of Holy Communion within the Catholic Church.