[7] On 29 June 2010, Molina moved to Andalusia's Real Betis (also in the second tier) for €1.6 million, with the player signing a four-year contract;[8] if his new club managed to promote at the end of the season, Elche were entitled to a €500,000 bonus.

[10] On 19 January 2011, in the domestic cup, he scored twice against FC Barcelona in a 3–1 home win (6–3 aggregate loss in the quarter-finals), thus ending the Catalans' unbeaten run of 28 games.

[11] The attacking trio of Molina, Rubén Castro and midfielder Achille Emaná totalled more than 50 league goals in 2010–11, as Betis returned to La Liga after two years of absence.

[17] On 31 August 2019, Molina scored in a 1–1 draw against Deportivo Alavés at the age of 37 years and 131 days, becoming the club's oldest player to achieve the feat in the Spanish top tier.

[25] Three days later, Molina scored in his third game in a row, thus becoming the oldest to do so in the main five leagues in the continent, completing the 2–1 comeback defeat of Atlético Madrid; this was also his eighth goal contribution in the last five fixtures, with only Bayer 04 Leverkusen's Patrik Schick having more in the same timeframe.

[29] After never suffering a muscle injury in his two-decade career, he was four games away from renewing when he ruptured his cruciate ligament on 12 March against SD Ponferradina;[30] he still helped his side to achieve promotion in July, and announced his retirement shortly after.