At the age of fourteen Entwisle joined the Methodists, and made use of a good library at the preacher's house in Oldham Street.

During the next few years Entwisle laboured in Leeds, Wakefield, Hull, Macclesfield, Manchester, Liverpool, and London, winning apopularity by his preaching power.

Henceforward he filled a leading place in the connexion, and did much to mould its policy and guide its affairs.

The later years of Entwisle's ministry were spent in Bristol, Birmingham, Sheffield, and London, where he was several times reappointed.

He ceased to itinerate in 1834, being appointed house governor of the new Theological Institution opened at Hoxton for the education and training of young ministers.