Joseph Knox Walker (July 19, 1818 – August 21, 1863) was an American politician and officer in the Confederate Army.

Soon after the beginning of the American Civil War, he entered the Confederate States Army and became colonel of the 2nd Tennessee Infantry Regiment.

Exposure in camp at Columbus, Kentucky, and afterward in the vicinity of the Siege of Corinth and Battle of Shiloh, impaired his health so seriously that he resigned his command.

The United States Army general commanding the department permitted him to return home to Memphis, Tennessee.

This article incorporates public domain material from the Yale Obituary Record.