Malchow as a venture capitalist supports high-tech companies with investment and advice on business formation and technology strategy.
At 16 he founded JetWare, a software company that developed and sold to consumers applications for Palm OS-powered mobile devices.
Publir is one of the largest invitation-only ad exchanges in the U.S. Digital media properties published by Malchow or monetized by companies he founded reach an average monthly audience of 35 million.
[15] In July 2021 Malchow investment Enovix Corporation, a Fremont, California-based maker of advanced lithium-ion batteries, went public.
[20] Malchow's investments include RelatelQ, Socotra, Sourcegraph, Material Security, Elementl, Retool, Premise Data, Golden, Mattermost, Solugen, and Flatfile.
[21] Malchow was a critic of the U.S. federal government response to the COVID-19 pandemic, writing in March 2020 in The Wall Street Journal that "a simple one-variable correlation of deaths per million and days to shutdown" showed that "[t]he correlation coefficient was 5.5%" and suggesting that the data "may prove that many aspects of the U.S. shutdown were mistakes—ineffective but economically devastating.
Shortly after the passage of the Inflation Reduction Act of 2022, Malchow wrote in The Wall Street Journal that "energy['s] future may mirror computing’s past.
"[23] Malchow was named to the board of directors of the National Civic Art Society in 2018, alongside Roger Scruton.