JHCPU is published by the Johns Hopkins University Press for Meharry and is affiliated with the Association of Clinicians for the Underserved.

The journal covers the health and health care of medically underserved populations in North and Central America, the Caribbean, and sub-Saharan Africa, as well as internally dispossessed Indigenous populations worldwide.

The topical scope is broad covering such areas as the epidemiology of inequities, structural racism, social determinants of health, quality, costs, regulation, legislation, and disease prevention.

Articles primarily take the form of scholarly research, as well as policy analyses and book reviews.

The journal is published quarterly in February, May, August, and November, with occasional supplemental issues.