Juan Alfonso Enríquez de Cabrera, 5th Duke of Medina de Rioseco

Juan Alfonso received his titles at the age of 3, when his father Luis III Enriquez de Cabrera died, under regency of his mother Italian Lady Vitoria Colonna (deceased 28 December 1633).

His mother, from Venezian and Roman families, was the daughter of Marcantonio II Colonna, (Civita Lavinia, 25 February 1535) – married, Rome, Italy, 29 April 1552 – Medinaceli, Spain, poisoned?, 1 August 1585), 3rd duke of Paliano, 1st duke of Tagliacozzo, count of Ceccano, lieutenant of the kingdom of Naples, Viceroy of Sicily, Knight of the Order of the Golden Fleece and Felice Orsini, deceased Rome, Italy 27 July 1596, the daughter of Girolamo Orsini, Sieur of Bracciano and Francesca Sforza, of the Counts of Santa Fiora.

She had married Luis III Enriquez de Cabrera in Vich, Catalonia, Spain, on 31 December 1587.

In 1638, he raised the Siege of Fuenterrabía by defeating a superior French army under Henri, Prince of Condé.

He had only two children, a daughter who died young in Naples, and the eldest and only one to survive him, a son named Juan Gaspar (1625-1691).