Juan Dominguez de Palermo (c. 1560 – 1635) was a Sicilian military officer and politician, who served in Buenos Aires during the Viceroyalty of Peru.

He served under the command of John of Austria, providing services in Malta, Naples and Spain.

[3] Established in the Río de la Plata by 1590,[4] he received land grants in Buenos Aires, being the owner of several haciendas in the suburbs of the city.

He was an active member of the City Council, serving as regidor for several years.

[7] His daughter Juana Gómez de Saravia, was married to Francisco de Melo Coutinho, son of João de Melo Coutinho and Juana Holguín, belonging to families of Vasco Fernandes Coutinho and Pedro Álvarez Holguín.