Hernangómez played a vital part in winning the EuroBasket with his home country Spain in 2022, scoring a game-high 27 points in the final against France.

[2] Additionally to his playing career, Hernangómez co-starred in the Netflix basketball film Hustle in 2022, alongside Adam Sandler.

He joined a youth squad of Real Madrid and played with the team until moving to Club Baloncesto Majadahonda for the following years.

The 2020–21 season was a tumultuous one for Hernangómez as he showed up to training camp out of shape, contracted COVID-19, and lost his spot in the starting lineup, capped off by a falling out with the Timberwolves front office over their decision to disallow him from participating in the 2021 Olympics after suffering a shoulder injury during an exhibition game.

[19] On 27 July 2022, Hernangómez signed a one-year contract with the Toronto Raptors for an amount equal to the veteran's minimum.

[21] On 27 July 2023, Hernangómez signed a two-year, 4,500,000€ deal with EuroLeague powerhouse Panathinaikos, returning to European basketball after seven years.

[25] In June 2018, Hernangomez was again named to the Spain national team's roster in advance of the first stage of qualifiers for the 2019 FIBA World Cup.

Hernangómez's style of play has drawn comparisons to NBA players Víctor Claver and Jonas Jerebko.

[31] Hernangómez made his acting debut in the Netflix film Hustle, produced by LeBron James and Adam Sandler, who is also the co-star.

His mother Margarita Geuer Draeger was an international basketball player, winning a European championship with Spain in 1993.