[2] On his mother's side, he was the nephew of Diego Deza, who would serve as his patron and mentor.

[2] He studied at the University of Salamanca, receiving a bachelor's degree in 1500 and a Licentiate of Canon Law in 1505.

[2] Pope Clement VII made Juan Pardo de Tavera a cardinal priest at the consistory of 22 February 1531.

[2] He subsequently received the red hat and the title of San Giovanni a Porta Latina at the consistory of 27 April 1531.

[2] Following the death of Isabella of Portugal on 1 May 1539, Charles V appointed Juan Pardo de Tavera regent of Castile in his absence, a post he would hold until 1541.