Directed by Malu L. Sevilla, Avel E. Sunpongco, Francis E. Pasion, Jojo A. Saguin, and Darnel Joy R. Villaflor, it stars Coco Martin in the title role.

It starred Coco Martin as Juan dela Cruz, a half-tagabantay and half-aswang who was trained to become the next Tagabantay and serves as a hero to protect the people from aswangs.

After a few weeks, Julian, Juan’s grandfather, escapes from prison to warn Amelia about the new prophecy—the Anak ng Dilim (Son of Darkness) who is set to be the most powerful Aswang to rule the people and the planet and destroy the Tagabantay.

Finally knowing about the prophecy, the Kapatiran, together with Julian’s guidance, soon start preparing Juan for a huge battle with the Haring Aswang and Anak ng Dilim.

[5] In August 2012, Cinemedia Films Production Incorporated and ABS-CBN Unit Head, Deo Endrinal confirmed that it would be serialised into a television drama to be directed by Malu Sevilla.

[6] Earlier reports claimed that Angel Locsin would be Martin's leading lady, after her two-year hiatus in television, but was later replaced by Erich Gonzales.

[7][8] It is under the production of Dreamscape Entertainment TV managed by Roldeo T. Endrinal and Julie Anne R. Benitez whose projects include the top-rating dramas Ina, Kapatid, Anak and Kailangan Ko'y Ikaw.

[10] A TV special titled "Juan dela Cruz: Ang Simula (The Beginning)" was aired on February 1, 2013, featuring exclusive behind-the-scenes footage and cast interviews of the highly anticipated drama, hosted by Kim Atienza.

[11] Jesse Lasaten and Von Guzman composed the show's background music using choir, duduk, bullroarer, Yamaha GX-1, and other instruments such as the balalaika for the Kapatiran theme in the drama with a full orchestra.

Jesse Lasaten, after doing work on the epic historical war film El Presidente, composed the background music of Juan Dela Cruz.

After 3 weeks of airing, Juan dela Cruz quickly rose to becoming one of the most successful action fantasy-drama of all time registering 42.6% viewership ratings nationwide according to the February 21 data released by Kantar Media.