She is best known for the discovery of cryoprecipitation, a process for creating concentrated blood clotting factors which significantly improved the quality of life for hemophiliacs around the world.

She left her graduate program when she gave birth to her two sons, Jonathan Robert and Jeremy David Pool,[1] in the 1940s.

She had a daughter twenty years after the birth of her second son, and married Maurice Sokolow, professor of medicine and hematology.

She finally completed her degree in 1946, produced a remarkable study of the electropotential of a single isolated muscle fiber.

In 1953, she began to do blood coagulation studies at the Stanford School of Medicine as a research fellow supported by a Bank of America-Giannini Foundation grant.

[2] Pool's major observation was that factor VIII can be simply and cheaply prepared from human plasma, and can be easily and safely given to hemophilic patients.