Julia Vargas Avenue is a central east–west arterial road that passes through Ortigas Center in Metro Manila, Philippines.

It is a four-lane divided road with one-way protected bike lanes that run parallel to Ortigas Avenue to the north and Shaw Boulevard to the south.

Between the next intersection at Lanuza Avenue and City Golf, Vargas is the boundary between Valle Verde 3 and 4 villages.

It passes the office towers in San Antonio, Pasig, toward the border with Barangay Wack-Wack Greenhills, Mandaluyong, at the intersection with ADB Avenue and San Miguel Avenue, where the El Pueblo Real de Manila strip mall is located.

At the western edge of Ortigas Center are St. Francis Square Mall, San Miguel Corporation Headquarters, and SM Megamall.