Profar spent 2015 with the High Desert Mavericks and Hickory, where he compiled a .266 batting average with four home runs and 33 RBI in 77 games between both teams.

Profar split the 2019 season between Frisco and the Nashville Sounds,[3] hitting a combined .265/.324/.394 with 10 home runs and 60 RBI.

[4] On November 22, 2019, Profar signed a minor league contract with the Boston Red Sox.

[5] Profar did not play in a game in 2020 due to the cancellation of the minor league season because of the COVID-19 pandemic.

[12] On October 23, 2023, Profar was selected in the sixth round by the Karachi Monarchs, with the 48th overall pick, of the 2023 Baseball United inaugural draft.

[19] His younger brother Jurdrick Profar signed his first professional contract with the Chicago White Sox in 2024.