He has previously played in Major League Baseball (MLB) for the Washington Nationals, Philadelphia Phillies, Cincinnati Reds, and Los Angeles Dodgers.

Bernadina was called up to the major leagues the first time on June 28, 2008 to replace the injured Lastings Milledge.

In the eighth inning, he "made a spectacular catch against the wall" against the Florida Marlins and fractured his right ankle, although he earned the nickname "The Shark.

The second came in the ninth inning off closerFrancisco Rodriguez, giving the Nationals the lead in a game they would ultimately win.

He also made a remarkable leaping catch in right field that likely robbed Met Jeff Francoeur of a bases-clearing triple.

[8][9] Bernadina finished the season, which would be his career high with 134 games played, with a .246 batting average, 11 home runs, and 16 stolen bases.

He finished the season with a similar batting line, hitting .243 with 7 home runs and 17 stolen bases.

He compiled a slash line of .291/.372/.405 and made several highlight defensive plays, including a game-ending catch against the left-center field fence at Minute Maid Park on August 7.

On August 19, 2013, the Nationals released Bernadina to clear a roster spot for David DeJesus, who was acquired from the Chicago Cubs.

[6] On January 31, 2014, Bernadina signed a minor league contract with the Cincinnati Reds that included a spring training invitation.

[17] After making the opening day roster,[18] he was designated for assignment on May 3 but was called back up to the Reds on May 5 after an injury to Jay Bruce.

[21] On June 27, Bernadina refused assignment to the Reds' minor league system and became a free agent.

[33] He led the league in runs, was named a KBO All-Star, and earned a Golden Glove Award.

[37][38] However, Bernadina left the Million Stars and signed with the Lamigo Monkeys of the Chinese Professional Baseball League on April 19.