K-25 was first designated as a state highway in 1927 and at that time began at K-45 west of Moscow, and ran north to the Nebraska border and continued as N-25.

The highways continue parallel to Cimarron Valley Railroad tracks for roughly 4.6 miles (7.4 km) then curves east.

The roadway passes north of an airport about 1.8 miles (2.9 km) later then enters the city of Hugoton as 11th Street.

K-25 and US-56 proceed north along Main Street for 1.3 miles (2.1 km) before curving northeast and exiting the city.

The highway continues through flat farmland for four point two miles (6.8 km) where it crosses the North Fork Cimarron River.

The highway proceeds through the city for about .5 miles (0.80 km) then crosses a Cimarron Valley Railroad track.

[5] The highway then passes by the Ulysses Airport for roughly 1.85 miles (2.98 km) then intersects County Road 9.

The highway advances north through flat farmland for about four miles (6.4 km) then enters into Kearny County.

[11] In a June 6, 1936 resolution, K-25 was slightly to eliminate two sharp curves, north of Lakin along the Kearny–Wichita county line.

[15][16] In a September 12, 1938 resolution, a 13.7-mile-long (22.0 km) section of K-25 was realigned southwest of Lakin to eliminate four sharp curves.

[18] In a March 30, 1950 resolution, K-25 and US-270 was realigned slightly east where it crosses the South Fork Cimarron River, just north of the Grant–Stevens county line.

[20] In two separate August 11, 1954 resolutions, Logan and Thomas counties had finished bringing the section of roadway, from west of Monument north to Colby, up to state highway standards.

[21][22] In a March 9, 1955 resolution, the highway was realigned south of Atwood to eliminate four sharp curves.