The station's studios and offices are located in the unincorporated Clark County community of Spring Valley, while its transmitter is atop Black Mountain in Henderson.

Its HD2 subchannel carries Channel Q, an Audacy format of LGBTQ talk and EDM dance music.

KXTZ beat the market's easy listening music competitor KEER-FM 97.1, forcing that station to switch formats in 1984.

[5][6] In December 2007, KMXB's "Mark & Mercedes in the Morning" scored the first post-rehab interview with Lindsay Lohan in a contest where listeners had to get celebrities to call in for Hannah Montana tickets.

During the run of the 2024 National Association of Broadcasters convention (typically shortened to "The NAB Show", and held annually at the Las Vegas Convention Center) in April of that year, KMXB-HD2 temporarily flipped to a micro-format branded as "Audacy Innovation Radio, Live from NAB", carrying an assortment of different formats with Audacy's in-house staffers running them; the intention was to show off new broadcasting innovations done to the equipment by both Audacy and broadcast system manufacturer Super Hi-Fi, and would effectively serve as a test run for new broadcasting equipment to be used on Audacy HD-broadcast stations nationwide, with the announcement made shortly after the convention on April 18; the station reverted to the Channel Q format at that time.