It can be transcribed into 15 transcript variants, which in turn can produce 13 different isoforms of the protein.
[12] KIAA0895 is semi-enriched in positively charged lysine and arginine groups, and positively and negatively charged lysine, arginine, glutamic acid and aspartic acid groups.
[12] However, KIAA0895 is semi-depleted in non-polar alanine, glycine and proline groups.
[16]KIAA0895 is predicted to undergo phosphorylation at several serines, threonines, and tyrosines throughout its structure.
Phosphorylation results in a conformational change in the structure of many enzymes and receptors.
Using a database called Mfold, a stem-loop formation for the 5' UTR region shows that there is a lack of conservation, meaning there is some precedence that these stems and loops are not used for translation regulation.
[18] Using the same database, a stem-loop formation for the 3' UTR region shows that there is conservation, meaning there is some precedence that they are used for translation regulation.
KIAA0895 is most commonly found in the testis, however it also has a strong expression in the kidneys, adrenal glands, and brain.
[6] Using an EST profile from NCBI, KIAA0895 has strong expression in cervical tumors and bladder carcinoma.