[7][8] Reading disability, or dyslexia, is a major social, educational and mental health problem.

In spite of average intelligence and adequate educational opportunities, 5 to 10% of school children have substantial reading deficits.

Twin and family studies have shown a substantial genetic component to this disorder, with heritable variation estimated at 50 to 70%.

[5] Mutations in the gene also more generally appear to play a key role in specific language impairment (SLI).

[9][10] The KIAA0319 protein is expressed on the cell membrane and may be involved in neuronal migration.