[8] An ortholog of KIAA1109 has been found in Drosophila, responsible for regulating synaptic vesicle recycling and certain brain related functions.

[8] According to data on NCBI's EST Abundance Profile page for KIAA1109, the gene is expressed in many different tissues in humans.

Human expression is seen most predominately in parathyroid, muscle, ear, eye, mammary gland, lymph node, thymus in addition to 27 other tissues.

KIAA1109 is also expressed in various disease states including 12 different tumors as well as bladder carcinoma, chondrosarcoma, glioma, leukemia, lymphoma, non-neoplasia, retinoblastoma tissues.

[13] According to Genomatix's ElDorado program the promoter region of KIAA1109 is predicted to be 601 base pairs in length.

[17] Birds also show fairly high conservation with mRNA sequence identities around 78% in zebra finches.

While conservation is still high the lower numbers may be due to small truncations on either, the 5’ and 3’ ends of these sequences.

[15] As we move to the more distant species of zebra fish and then the red four beetle and carpenter ant the conservations drops.

[24] KIAA1109 is predicted to undergo various types of post translational modifications including glycate, N-glycosylation, O-GlcNAc, O Glycosylation, Sulfonation and Phosphorylation.

[26] MADH2 and Beta-catenin were both found to have a physical interaction with my protein as detached by display technonloy by Miyamoto-Sato et al.