KILT shares its call sign with its sister station KILT-FM (100.3 FM), which airs a country music radio format.

On weekdays, KILT has local hosts from morning drive time through the evening, with CBS Sports Radio syndicated national programming heard late nights and weekends.

In 1952, KLEE was sold to Gordon McLendon, who initially changed the call letters to KLBS, to represent his network, the "Liberty Broadcasting System."

Notable personalities in the 1960s and 1970s included Steve Lundy, Sheila Mayhew, Beau Weaver, Butch Brady, Jay West, K.O.

On February 16, 1981, sister station KILT-FM dropped album rock for country during the "Urban Cowboy" craze that swept through Houston, and the United States in general.

The initial hosts were Mike Edmonds & Ed Fowler in the afternoon from 4-7 p.m. and the Bob Stevenson Outdoors Show, airing Tuesday-Friday mornings 4am-5am and Saturdays & Sundays from 4am-7am.

In 1995, Edmonds & Fowler moved to the mornings 6am-9am and Rich Lord & Kenny Hand were paired together for "Section 610" from 4pm-7pm.

Lord & Hand also alternated hosting duties for the locally produced Astros Clubhouse Extra post-game shows from 1996 to 1998.

KILT's local sports talk programming was expanded in the late 1990s as Nate Griffin, Lance Zierlein, John Granato, Tony Ortiz (as of 2024 at WWJ-AM in Detroit), Michael P. Davis, Adam Wexler, Russ Small, Jeremy Foster and Matt Jackson all joined the station for various timeslots.

In 2001, KILT signed a 10-year agreement with the expansion Houston Texans of the NFL to become their first-ever flagship radio station when the team began play in 2002.

In 2007, Lord moved on to a new role, serving seven seasons as the Texans in-game sideline reporter before giving way to John Harris.

As of 2024, longtime local hosts on SportsRadio 610 included: Sean Pendergast, Seth Payne, and John P. Lopez.