1IM9, 1NKR3802n/aENSG00000278755ENSG00000278495ENSG00000278738ENSG00000278248ENSG00000278503ENSG00000284530ENSG00000276820ENSG00000275080ENSG00000275276ENSG00000273794ENSG00000276625ENSG00000277616ENSG00000284100ENSG00000284514ENSG00000283723ENSG00000274926ENSG00000278207ENSG00000274782ENSG00000284347ENSG00000273510ENSG00000274692ENSG00000277833ENSG00000276310ENSG00000284551ENSG00000275750ENSG00000275522ENSG00000277356ENSG00000284145n/aP43626n/aNM_014218n/aNP_055033n/aKiller cell immunoglobulin-like receptor 2DL1 is a protein that in humans is encoded by the KIR2DL1 gene.

The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC).

KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals.

The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

[5] KIR2DL1 has been shown to interact with HLA-C.[6][7][8][9] This article incorporates text from the United States National Library of Medicine, which is in the public domain.