Owned by Inyo Broadcast Holdings, the station maintains offices on Railway Drive in north Oklahoma City, and its transmitter is located near 122nd Street on the city's northeast side.
The station first signed on the air on March 16, 1996, as KMNZ; it was originally an affiliate of the Infomall TV Network (inTV), a service operated by Paxson Communications that specialized in paid programming.
On August 31, 1998, KOPX became a charter station of the family-oriented Pax TV network (later reformatted into a general entertainment service as i: Independent Television, now Ion Television), with religious programming from The Worship Network airing during the overnight hours.
[2] The news share agreement ended on June 30, 2005 (coinciding with Pax's rebranding as i: Independent Television), due to Paxson Communications' decision to discontinue carriage of network affiliate newscasts as a result of Pax's financial troubles.
As a part of the repacking process following the 2016–2017 FCC incentive auction, KOPX-TV relocated to UHF channel 18 in 2019.