[4] KYKY broadcasts three HD Radio signals, with the first airing its main hot adult contemporary format.

In 2023, KYKY acquired the radio broadcast rights to St Louis City SC matches.

In September 2005, KYKY, sister station KEZK-FM, and television partners KSDK and KETC simulcast a telethon for Hurricane Katrina relief that raised more than $5 million.

The telethon featured an appearance by actor John Goodman, a native of Affton, Missouri who now calls New Orleans his home and whose family was actually missing for a time during the storm's peak.

Singer Sheryl Crow, a native of Kennett, Missouri, and her then-fiancé Lance Armstrong, urged viewers to call when they were interviewed by telephone from the region.