Kaa-Iya del Gran Chaco is linked with Otuquis National Park and newly created Ñembi Guasu conservation area, covering about 60,000 km2 of Gran-Chaco forest.

A camera trap study by WCS estimated that there are over 1000 jaguars living within the park which makes it one of the most important areas for the survival of these big cats.

The greatest concentration of people is found towards the west (Bañados de Izoso), in the area's power base, where there are more than twenty Guaraní communities, including Guarirenda, Rincón, Huirapendi, Guirayasa, Coropo, Cacharí, Aguraigua, Guirapendio, Isiporenda, and Yapiroa.

The ruins of San Ignacio de Zamucos, a Jesuit mission that was active from 1724 to 1745, are located in the southeastern end of the Kaa-Iya del Gran Chaco National Park.

This park, despite its low prominence and the apparent monotony of its countryside, is of great interest due to the enormous richness of its wildlife for the development of eco- and adventure-tourism.

The presence of representatives of the indigenous Izoceño, Chiquitano and Ayorea populations increases the importance of the area; among other cultural expressions, they produced very stylised craftwork.

There are historic sites in the power base of the region, e.g. the Missions of San José de Chiquitos and Santa Cruz la Vieja.

The biological diversity of the Protected Area is due to variability in climate and soil conditions, as well as the lack of availability of water, which influence the unusual flora and fauna of the region.

From San José de Chiquitos there is a bridlepath which joins Fortín Ravelo and Suárez Arana, forming the most stable path in the extreme east of the Area.