Kalisizo is a town in the southern part of the Central Region of Uganda.

Kalisizo lies on the main highway between Masaka and the border town of Mutukula on Uganda's border with Tanzania.

Kalisizo is located approximately 29 kilometres (18 mi), by road, southwest of Masaka, the nearest large city.

[1] Kalisizo is approximately 61 kilometres (38 mi), by road, north of Mutukula, the town at the international border with Tanzania.

[3] In 2010, the Uganda Bureau of Statistics estimated the population of the town at 32,000, compared to 32,700 in 2011.