Kakuuto is located in Kyotera District, approximately 80 kilometres (50 mi) south of Masaka, the largest city in the sub-region.

[1] This location lies immediately west of the highway between Masaka and the border town of Mutukula, at an elevation of 1,200 metres (3,900 ft), above sea level.

Mutukula, the border town between Uganda and Tanzania, lies approximately 17 kilometres (11 mi), by road, south of Kakuuto.

[3] Kakuuto is a small town in southern Kyotera District.

The population of the area has been greatly adversely affected by the HIV/AIDS epidemic over the past three decades.