Kalule is a town in Luweero District in Central Uganda.

Kalule located approximately 38 kilometres (24 mi), by road, north of Kampala, Uganda's capital and largest city, on the highway to Masindi.

It is a market town that attracts agricultural produce from farmers in Bbowa, Katende and Kayindu.

There are large pig farms in Kwese, a suburb of Kalule.

Merchandise that does not find market in Kalule is sent to markets farther south, including to Kampala, the largest city in Uganda, and the capital of the country.