It is the main municipal, administrative, and commercial center of Luweero District.

[2] In 1982, in the Ugandan Civil War, Milton Obote's soldiers raided their village, from Kampala.

Luweero is approximately 62 kilometres (39 mi), by road, north of Kampala, Uganda's capital and largest city, on the highway to Masindi.

In 2010, the Uganda Bureau of Statistics (UBOS) estimated the population at approximately 28,800.

UBOS calculated that the population of Luweero Town increased at an average estimated rate of 2.4 percent per year, between 2015 and 2020.