Kampala Speke Hotel is a hotel in Kampala, the capital and largest city in Uganda, the third-largest economy in the East African Community.

This location is close to banks, shopping arcades and offices, in the middle of Kampala's central business district.

Over the years, despite numerous renovations and upgrades, Speke Hotel has retained its colonial ambiance.

The hotel has fifty en-suite rooms, several themed restaurants (including Italian and Indian) and a cocktail bar.

As of July 2014, the hotels of the Ruparelia Group include: