[1][2] The hospital is located in an area of the city of Lilongwe called Area 33 (also Nangwagwa), south of the Lingazi Namilomba Forest Reserve and the Lilongwe Wildlife Centre; adjacent to Kamuzu College of Nursing.

[5] The hospital was built in 1977 by the Danish International Development Agency (DANIDA), with money provided by the government of Denmark.

[6] Kamuzu Central Hospital has a partnership with the University of North Carolina.

The objective of the collaboration is to "identify innovative, culturally acceptable, and affordable methods to improve the health of the people of Malawi, through research, capacity building, and care".

[7] The hospital also receives support from Baylor Pediatric AIDS Initiative (BIPAI).