The year 2000 was also the time period when McClure played a recurring role in the Canadian drama television series Da Vinci’s Inquest.

[10] Also in 2002, McClure guest starred as Annie Fisher in two episodes of James Cameron's science fiction drama television series Dark Angel on Fox.

[14] In 2011 McClure played the girlfriend of Stuart Davis in the independent short film Just Be Yourself, a comedy about a desperate man who is offered a job to "just be himself.

[17] In 2012 McClure joined the cast of Netflix original series Hemlock Grove (premiered in January 2013[12])[18] and completed the feature film Broken Kingdom (alongside Rachael Leigh Cook).

[9] On 2 February 2016, Historica Canada featured Viola Desmond in the 82nd Heritage Minute,[19] to mark the beginning of Black History Month.

It features Kandyse McClure as Viola Desmond,[20] a civil rights activist and entrepreneur who challenged segregation in Nova Scotia in the 1940s.