On 11 July 2011, the Sindh Government restored Karachi South District.

Now Karachi South comprise Saddar along with Clifton and Defence area.

[4] At the time of the 2023 census, 808,465 of the population spoke Urdu, 363,930 Sindhi, 269,872 Balochi, 219,474 Pashto, 190,438 Punjabi, 86,498 Hindko and 61,543 Saraiki, 5,370 Kashmiri, 8,434 Brahui, 498 Shina, 1,169 Balti, 1,501 Mewati, 56 Kalasha, 551 Kohistani, 311,965 others as their first language.

A large percentage of the population speaks languages recorded as other on the census, such as Gujarati.

Hinduism (including Scheduled Castes) is practiced by 4.24% and Christianity by 1.65% of the population.