[2] DeCrow joined the National Organization for Women (NOW) in 1967, after she and her female coworkers at a publishing house realized they were earning less than men.

1970) established that, as a public place, the ale house had violated the Equal Protection Clause of the United States Constitution.

[8][9] In 1972, she was a part of the Ms. magazine campaign: “We Have Had Abortions” which called for an end to "archaic laws" limiting reproductive freedom, and encouraged women to share their stories and take action.

[10] In 1981, DeCrow was one of the lawyers for former NYPD detective Frank Serpico in his unsuccessful attempt to overturn a child support order on the grounds that the mother had deceived him into the pregnancy by lying about taking the contraceptive pill.

She told the court “Autonomous women making independent decisions about their lives should not expect men to finance their choice.”[11] DeCrow was elected president of NOW from 1974 to 1977, during which time she led campaigns to ensure that collegiate sports would be included under the scope of Title IX, pressured NASA to recruit women as astronauts, oversaw the opening of a new NOW Action Center in Washington, D.C., and the establishment of NOW's National Task Force on Battered Women/Household Violence, and participated in a tour of over 80 public debates with antifeminist activist Phyllis Schlafly over the Equal Rights Amendment.

[5] DeCrow described her ultimate goal as "a world in which the gender of a baby will have little to no relevance in future pursuits and pleasures—personal, political, economic, social and professional.